Endocrine Abstracts

Objective: PTP1B is a protein tyrosine-phosphatase, predominantly localized on the endoplasmic reticulum, which plays a major role in the regulation of the tyrosine-kinase activity of the insulin receptor (IR). A better understanding of the dynamics of the interaction between the IR and PTP1B constitutes a major task for the development of compounds that will improve insulin sensitivity.Methods: The BRET methodology represents a major advance for the stu...